A decade ago, the importance of implementation science was recognized by the U.S. Department of Education Office of Special Education Programs (OSEP) and led to the development of what is now the State Implementation and Scaling up of Evidence-Based Programs (SISEP) Center. The design of SISEP’s work in state education systems is based on the developing field of implementation science. As such, SISEP makes use of the best available evidence in implementation practice, science, and policy. In 2014, the SISEP Center completed Year 6 of its work with states. The purpose of this document is to summarize key findings.